Microneedling with PRP vs Exosomes: Which Is Better?

Spoiler: They’re both powerful—but one is taking skin regeneration to the next level.

At Sorelle Aesthetics Clinic Birmingham, we’re all about cutting-edge, non-surgical skin solutions that deliver visible results—and microneedling is at the heart of many of our advanced skin treatments. But when it comes to what to combine it with for maximum results, the big question we get is:

Should I choose PRP (Platelet-Rich Plasma) or Exosomes with my microneedling?

Let’s break it down…

What Is Microneedling?

Microneedling—especially with the Dermapen 4 we use at our clinic—is a collagen-induction therapy designed to create microchannels in the skin that trigger a natural repair response. This stimulates collagen, elastin, and a brighter, more even skin tone.

Learn more about our Microneedling Treatment in Birmingham

Microneedling with PRP: The “Vampire Facial” Effect

PRP (Platelet-Rich Plasma) involves using your own blood—specifically the golden plasma rich in growth factors—to accelerate skin healing and regeneration after microneedling. It’s natural, safe, and has been loved by celebs for years.

Benefits of Microneedling + PRP:

✅ Boosts collagen and elastin
✅ Speeds up healing post-treatment
✅ Improves tone, texture, and acne scarring
✅ Natural and autologous (from your own body)

Microneedling with Exosomes: The Future of Skin Regeneration

Exosomes are tiny messengers derived from stem cells. They’re packed with growth factors, peptides, and anti-inflammatory signals that supercharge your skin’s repair process. Further reading here

At Sorelle, we use clinical-grade exosomes as part of our most advanced facials—like our new Luminous Facial, which combines microneedling with marine-derived PDRN (a form of exosome-like therapy) for maximum collagen stimulation.

Benefits of Microneedling + Exosomes:

✨ Accelerates skin healing
✨ Deeply hydrates and brightens
✨ Minimises pigmentation and fine lines
✨ Supports anti-ageing at a cellular level
✨ Ideal for sensitive, mature, or inflamed skin

So… What’s Better? PRP or Exosomes?

The honest answer: It depends on your skin goals.

Skin Concern	Best Option
Acne scars or post-acne marks	PRP or Exosomes
Ageing skin, pigmentation, or dullness	Exosomes
Redness, sensitivity, or rosacea	Exosomes
Wanting a natural, bio-identical option	PRP

At Sorelle Aesthetics, we always start with an in-depth skin consultation to assess which method will suit you best. In some cases, we may even combine both to target multiple concerns.

❓1. Which gives faster results—PRP or exosomes with microneedling?

Exosomes tend to deliver faster visible improvements—especially in brightness, hydration, and overall glow—because they contain concentrated growth factors and peptides that rapidly boost skin regeneration. PRP is effective too, but results are typically more gradual as it relies on your body’s own natural healing response.

❓2. Are exosomes better for mature or ageing skin than PRP?

Yes—exosomes are ideal for ageing skin because they help repair skin at a cellular level, reduce inflammation, and stimulate long-term collagen and elastin production. They’re particularly effective for treating fine lines, sun damage, pigmentation, and skin thinning—common concerns for women over 40.

❓3. Can I combine PRP and exosomes for better results?

Absolutely. At Sorelle Aesthetics, we sometimes recommend combining PRP and exosomes for clients with multiple concerns—like acne scarring, pigmentation, and ageing. During your consultation, we’ll create a personalised plan based on your skin goals to maximise results from your microneedling treatment.

💡 Client Favourite: The Luminous Facial

If you’re looking for the ultimate glow-up, our signature Luminous Facial combines Dermapen 4 microneedling with PDRN (marine-derived polynucleotides)—a powerful regenerative treatment that behaves much like exosomes.

It’s ideal for:

✔ Ageing, tired, or lacklustre skin
✔ Fine lines, sun damage, and pigmentation
✔ Boosting collagen and hydration from deep within